Exosomes in Korea are used as a topical skin booster: a solution of exosomes is spread over the face right after microneedling or RF microneedling opens tiny channels, so it can be absorbed into the skin. A session usually takes 60 to 90 minutes, with numbing cream applied for 30 to 40 minutes before the needling step. Redness typically settles within a few days, and flying home the same day is generally possible. Changes in texture and glow tend to show over two to four weeks, often across a course of sessions. Clinics usually price per session or per package of sessions, before VAT. This page lists clinics that offer it and a table of current prices.
Is it for you?
Who Exosome therapy in Gangnam suits, and who should wait
Exosome care is commonly used for dull or uneven texture, fine lines, enlarged pores, mild acne scarring and skin that feels tired after travel or sun. It suits people who already plan a microneedling or RF microneedling session and want a soothing, recovery-focused product applied afterward, rather than a separate procedure on its own.
It is not a lifting treatment and does not restore lost volume. Deep folds, marked sagging and heavy jowls call for other options, such as focused ultrasound, radiofrequency lifting, filler or surgery. People with active infection, open wounds or a flare of eczema on the face should wait until the skin has healed, and anyone pregnant should postpone elective needling.
Usually a good fit
- Dull, rough or uneven skin texture
- Fine lines and early loss of firmness
- Enlarged pores or shallow acne scars
- Planning microneedling and wanting calmer recovery
May be better to wait
- Pregnancy or breastfeeding
- Active acne cysts, herpes or eczema on the face
- Gold threads or metal implants in the treated area
- Sagging that needs lifting, filler or surgery
Clinics in Gangnam
10 clinics for Exosome therapy in Gangnam
Every clinic below lists Exosome therapy among its treatments. Message a clinic directly.
1RE:BERRY Clinic Gangnam
2
3Cleor Clinic Gangnam
4REPIC Clinic Gangnam
5Medicube Clinic
6Cellon Dermatology Clinic (Cheongdam)
7
8ADO Clinic
9
10How it works
How a Exosome therapy session runs
Exosomes are tiny vesicles released by cells, carrying proteins, lipids and RNA that act as signals between cells. Most aesthetic products are made from the culture medium of human stem cells, then freeze-dried and mixed with a diluent just before use. In Korea these products are sold as cosmetics, so clinics apply them to the skin surface and let them absorb through channels created by a device, instead of placing them under the skin with a needle.
The device step does most of the physical work. Potenza delivers radiofrequency through insulated microneedles at adjustable depths of 0.5 to 3.5 mm, while classic microneedling (MTS) uses fine needles without energy, and LDM uses local micro-vibration to calm the skin. A 2025 review by Nahm and colleagues in the International Journal of Dermatology found clinical reports on skin aging, scarring, hair and melasma, but noted that isolation methods and product standards still vary widely.
What sets the price unit in Korea is the combination: the needling device and depth, the face area covered, the exosome product and vial size, and whether a soothing mask or LDM is added. Product brands differ between clinics; one Korean example is ASCE+ by ExoCoBio, a freeze-dried exosome kit.
Skin assessment
The treating doctor checks texture, scars, pores and any active inflammation, then chooses the device, needle depth and areas. Expect 10 to 15 minutes, including photos.
Cleansing and numbing
Makeup is removed and a numbing cream is left on for 30 to 40 minutes, because the needling step is uncomfortable without it.
Microneedling or RF microneedling
The device passes over each area in a set pattern, opening micro-channels. This part usually takes 15 to 25 minutes for a full face.
Exosome application
The freeze-dried exosome powder is mixed with its diluent and spread over the treated skin, then pressed in or worked with LDM so it absorbs while the channels are open.
Soothing and aftercare briefing
A calming mask or cooling step follows for about 10 to 15 minutes, and staff explain cleansing, sunscreen and what to avoid over the next few days.
Exosome therapy compared with other options
| Feature | Topical exosomes | Rejuran (PN) | Hyaluronic acid booster |
|---|---|---|---|
| What goes on or in the skin | Exosome solution absorbed after needling | Polynucleotide placed by fine needle | Hyaluronic acid placed by fine needle |
| Main effect sought | Texture, glow and recovery support | Skin quality and thin, tired skin | Hydration and fine-line softening |
| How it reaches the skin | Through channels from the device step | Small deposits across the face | Small deposits across the face |
| Typical visible marks | Redness for one to three days | Small bumps for one to three days | Small bumps or pinpoint bruises |
| Usual course | Several sessions a few weeks apart | Two to three sessions a few weeks apart | One to three sessions |
At a glance
Exosome therapy facts
| Product type | Exosome solution, usually from stem cell culture medium, freeze-dried |
|---|---|
| Korean example | ASCE+ by ExoCoBio (product brands vary by clinic) |
| How it is used | Applied to the skin and absorbed right after needling |
| Paired devices | Potenza RF microneedling, microneedling (MTS) or LDM |
| Numbing | Topical cream for 30 to 40 minutes |
| Session length | About 60 to 90 minutes in total |
| Downtime | Redness for a few hours to a few days |
| Usual sessions | A course of several sessions, a few weeks apart |
| Earliest flight home | Generally the same day |
Recovery
What the days after look like
The face looks pink to red and feels warm and tight, similar to a mild sunburn. Skip makeup until the next morning.
Redness fades and the skin may feel dry or rough. Pinpoint marks from the needles can stay visible a little longer after deeper RF microneedling.
Fine flaking settles and most people return to normal skincare. Daily sunscreen matters more than usual during this week.
Texture, glow and evenness start to change as the skin renews. Many clinics plan the next session around this point.
Results build over the full series and then depend on sun protection, skincare and maintenance visits.
Safety
Exosome therapy risks and limits
- Redness, warmth, swelling and tightness for hours to a few days are common after the needling step.
- Pinpoint marks, dryness or fine flaking can last up to a week.
- Breakouts, irritation or contact reactions to the product can occur, and infection is possible if aftercare is skipped.
- Darker skin types carry a risk of temporary post-inflammatory pigmentation after RF microneedling.
- Product standards and long-term data on exosomes are still limited, so results vary from person to person.
- It does not lift sagging skin or replace lost volume.
Evidence
Research behind this page
- Exosomes in Dermatology: A Comprehensive Review of Current Applications, Clinical Evidence, and Future DirectionsInternational Journal of Dermatology · 2025 · Nahm W, Nikas C, Goldust M, Horneck N, Cervantes J, Burshtein J, et al. · doi:10.1111/ijd.17903
Review describing exosome products in dermatology, clinical reports on aging, scarring, hair and melasma, and gaps in isolation standards and regulation.
- Clinical Advances in Exosome-Based Therapies for Aesthetic Medicine: A Systematic Review and Meta-analysis of Human Clinical TrialsAesthetic Surgery Journal · 2026 · Stack E, Spongberg C, Braud S, Stanton W, Elway M, et al. · doi:10.1093/asj/sjaf178
Systematic review of 39 human studies reporting an average facial wrinkle reduction of about 20%, while noting heterogeneity and nonstandardized protocols.
- Counseling Patients on Exosomes in Aesthetic Dermatology: A Viewpoint on Evidence, Regulation, and ConsentInternational Journal of Dermatology · 2026 · Mrigpuri S · doi:10.1111/ijd.70693
Viewpoint on how to discuss the current evidence, regulatory status and informed consent with patients considering exosome treatments.
FAQ
Questions about Exosome therapy in Gangnam
Are exosomes in Korea applied on the skin or put under it?
In Korea, exosome products are applied to the skin surface right after a needling device has opened micro-channels. They are sold as cosmetics, so clinics spread them over the treated area rather than placing them under the skin. The needling step, such as Potenza RF microneedling or classic microneedling, creates the pathway for absorption. If a clinic describes something different, ask exactly how the product is used and what it is.
Is an exosome skin booster in Korea the same as Rejuran?
No, they are different products used in different ways. Rejuran is a polynucleotide placed by fine needle in small deposits, while an exosome skin booster in Korea is absorbed through channels made by microneedling. Some people combine them on separate visits. A consultation can explain which one fits your skin goal, recovery window and travel dates.
Is exosome care uncomfortable?
It feels prickly and warm, but numbing cream makes it tolerable for most people. The cream stays on for 30 to 40 minutes before the device step, and deeper RF microneedling feels stronger than shallow passes. The exosome application itself is gentle, closer to a serum being pressed in. Tell the doctor if an area feels too sharp so the depth or settings can be adjusted.
How soon can I board a flight after a session?
Flying is generally possible the same day or the day after. The skin will look pink and feel dry, so bring the clinic's soothing products and a hydrating mist for the cabin. Avoid makeup until the next morning and keep the face clean during travel. If photos or events are planned, allow about a week for redness and fine flaking to settle.
What does the research on exosomes show so far?
Early human studies are encouraging but still limited. In a 2026 systematic review in the Aesthetic Surgery Journal, Stack and colleagues pooled 39 studies and found facial wrinkle reduction averaged about 20%, with improvements in pigmentation, elasticity and texture. The authors also noted that protocols and products were not standardized. A 2026 viewpoint by Mrigpuri in the International Journal of Dermatology urges clear counseling on evidence, regulation and consent.
How many sessions are usually needed?
Most clinics suggest a course of several sessions spaced a few weeks apart. Skin renewal after needling takes time, so the change builds across the series rather than after one visit. Texture concerns may need fewer sessions than scarring. Visitors on short trips often do one session in Korea and continue the plan at home or on a later visit.
How long do the results last?
Results vary from person to person and fade gradually as the skin ages. The effect depends on how many sessions were done, the depth of needling, daily sun protection and skincare. Many people book maintenance sessions every few months. Smoking and heavy sun exposure shorten the benefit.
Which treatments pair with exosomes on one trip?
Yes, but the order and spacing should be planned by the treating doctor. Lifting with focused ultrasound or radiofrequency is often done on a separate day, and resurfacing lasers may need a gap from deeper needling. Combining too much on one day raises irritation risk. Share your full trip schedule at consultation so sessions can be spaced sensibly.
How can I check which exosome product is being used?
Ask to see the sealed vial or kit and the product name before treatment. Freeze-dried kits come with a separate diluent and should be mixed in front of you. Note the brand, batch and expiry date for your records. Clear product details make later aftercare questions easier.
Do listed prices include VAT?
Prices in Korea are usually listed before VAT, and 10% VAT is added at payment. Check whether a quote covers the needling device, the exosome product, numbing and the soothing step, or only part of the session. Packages of several sessions are common. The price table on this page shows current listed prices so quotes can be compared on the same basis.